seminal levels of pro-inflammatory (cxcl1, cxcl9, cxcl10) and homeostatic (cxcl12) chemokines in men with asymptomatic chlamydia trachomatis infection

نویسندگان

hamid hakimi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran

nahid zainodini immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran

hossein khorramdelazad molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, ir iran

mohammad kazemi arababadi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, ir iran

چکیده

background chemokines play important roles in immune system activation against microbial infections. objectives the current study aimed to evaluate seminal levels of cxc chemokines cxcl1, cxcl9, cxcl10 and cxcl12 in chlamydia trachomatis infected patients. materials and methods the c. trachomatis infection was determined employing polymerase chain reaction (pcr)-based methods. seminal concentrations of cxcl1, cxcl9, cxcl10 and cxcl12 were measured by enzyme-linked immunosorbent assay (elisa). results the current study results demonstrated that the semen levels of cxcl1 and cxcl9, but not cxcl10 and cxcl12, significantly increased in c. trachomatis infected patients compared to the healthy controls. conclusions based on the current study results, it may be concluded that both cxcl1 and cxcl9 play more important roles than cxcl10 and cxcl12 in induction of immune responses against c. trachomatis and could possibly be considered as future targets for immunotherapy of c. trachomatis infection.

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عنوان ژورنال:
jundishapur journal of microbiology

جلد ۷، شماره ۱۲، صفحات ۰-۰

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